For those who may have some difficulty in understanding how mass vaccination drives viral immune escape…by Geert Vanden Bossche, DVM, PhD

Over the last week, we have been sharing compelling informaton on how Covid-19 can take advantage of suboptmal S-specifc antbodies (Abs) to evade the host immune system. The virus will only exploit this opportunity when the immune pressure raises to a point where its replicaton is jeopardized. As previously explained, Covid-19 will implement this ‘escape’ strategy when its replicaton becomes severely hampered, e.g., due to stringent infecton preventon measures (hence why we’re now dealing with an increasing number of highly infectous variants). Mass vaccinaton will dramatcally increase immune pressure on the virus while opening additonal emergency exits. Because of enhanced infectousness and spread of Covid-19, the virus will, indeed, increasingly infect subjects whose Abs are suboptmal (because too low in concentraton and/ or afnity). Suboptmal Abs enable the virus to select mutatons capable of strengthening its binding to the ACE2 receptor, thereby enhancing its infectousness and eventually allowing ACE2 to outcompete vaccinal Abs for binding to its spike protein (resultng in viral resistance to the vaccines) .

For those who may have some difculty in understanding how mass vaccinaton drives viral immune escape, it will sufce to watch infectvity and morbidity rates in those countries who have now succeeded in vaccinatng millions of people in just a few weeks (e.g., UK, Israel, USA). Whereas these countries are now enjoying declining infectvity rates, they will undoubtedly start to sufer from a steep incline in Covid-19 cases in the weeks to come. The steep decline we’re seeing right now may be followed by a short-lived plateau but a subsequent steep incline of (severe) disease cases is inevitable.

Unfortunately, it’s only when the world will witness how morbidity and fatality rates start to dramatcallyincrease despite ever growing vaccine coverage rates that health policy makers will fnally realize that things are going in the wrong directon. Only then will the disastrous consequences of mass vaccinaton campaigns become obvious to WHO and our politcal leaders. Unfortunately, this may stll take another couple of weeks. The price to be paid for the loss of this precious tme is just beyond what one can imagine.

About budbromley

Bud is a retired life sciences executive. Bud's entrepreneurial leadership exceeded three decades. He was the senior business development, marketing and sales executive at four public corporations, each company a supplier of analytical and life sciences instrumentation, software, consumables and service. Prior to those positions, his 19 year career in Hewlett-Packard Company's Analytical Products Group included worldwide sales and marketing responsibility for Bioscience Products, Global Accounts and the International Olympic Committee, as well as international management assignments based in Japan and Latin America. Bud has visited and worked in more than 65 countries and lived and worked in 3 countries.
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