“..increasing vaccination rates will result in a gradually expanding reservoir of asymptomatic viral spreaders.”

and “more efficient reproduction and propagation of vaccine-resistant immune escape variants.”

Geert Vanden Bossche, PhD, DVM, vaccine developer:

“…mass vaccination will ultimately enable the virus to adapt to suboptimal S-directed immune pressure exerted by previously asymptomatically infected people. This broadly exerted selective immune pressure on viral transmissibility will enable more infectious Sars-CoV-2 variants to become dominant. The more people get vaccinated, the more young and healthy or otherwise non-susceptible people will be turned into (potential) asymptomatic carriers, thereby enabling more infectious variants to reproduce more effectively. When mass vaccination campaigns are extended to younger age groups, more and more subjects who – upon natural infection – would normally shed virus for only a short period of time will now contribute to expanding this breeding ground. This is likely due to the time needed for vaccinees to mount a full-fledged immune response and the potential mismatch between the S protein of the vaccine and that of the circulating variant. As mass vaccination increasingly includes younger people, the impact thereof on reducing the infectious pressure in the population will diminish. This is because the impact of their vaccination on the number of prevented cases of disease is much less pronounced. Instead, enhanced vaccination rates will raise the S-directed immune pressure in that it will gradually shift to targeting the receptor-binding domain (RBD) of the virus, thereby resulting in more efficient reproduction and propagation of vaccine-resistant immune escape variants.”

“Conclusion: As increasing vaccination rates will result in a gradually expanding reservoir of asymptomatic viral spreaders, the benefit of reduced disease and hence, reduced viral shedding in vaccinated elderly (or otherwise vulnerable subjects) will be countered by enhanced spread and breeding of more infectious variants in the less vulnerable part of the population. The higher the vaccination rate, the more the latter effect will outweigh the benefit of vaccine-mediated reduction of immune pressure exerted by the vulnerable part of the population. Concomitant implementation of stringent infection prevention measures will merely delay but not prevent the vaccine-mediated impact of diminished Covid-19 morbidity rates in the elderly (or otherwise vulnerable subjects) on the evolution of the virus in younger and healthy subjects. The more younger and healthy age groups will be enrolled in these mass vaccination campaigns, the faster the predominantly circulating Sars-CoV-2 will evolve to more infectious, and ultimately vaccine-resistant variants.”

Answer to FAQ#4: https://www.geertvandenbossche.org/faq

Possible example: https://trialsitenews.com/japanese-study-indicates-lambda-could-be-resistant-to-vaccines/#comments

About budbromley

Bud is a retired life sciences executive. Bud's entrepreneurial leadership exceeded three decades. He was the senior business development, marketing and sales executive at four public corporations, each company a supplier of analytical and life sciences instrumentation, software, consumables and service. Prior to those positions, his 19 year career in Hewlett-Packard Company's Analytical Products Group included worldwide sales and marketing responsibility for Bioscience Products, Global Accounts and the International Olympic Committee, as well as international management assignments based in Japan and Latin America. Bud has visited and worked in more than 65 countries and lived and worked in 3 countries.
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