A better way for Covid patients?

A better approach could be to genotype patients to determine their risk profile and best treatment, rather than testing everyone for infection and “vaccinating” everyone.

Genetic mechanisms of critical illness in Covid-19. Published Dec 2020.

GWAS study of 2244 critically ill patients.

“…There is now strong evidence that critical illness caused by Covid-19 is qualitatively different from mild or moderate disease, even among hospitalised patients. There are multiple distinct disease phenotypes with differing patterns of presenting symptoms13 and marked differential responses to immunosuppressive therapy.2 In patients without respiratory failure, there is a trend towards harm from treatment with corticosteroids, whereas among patients with critical respiratory failure, there is a very substantial benefit.2 On this basis, we consider patients with critical Covid-19 respiratory failure to have distinct pathophysiology. … We have discovered new and highly plausible genetic associations with critical illness in Covid -19.”

Pairo-Castineira, E., Clohisey, S., Klaric, L. et al. Genetic mechanisms of critical illness in Covid-19. Nature (2020).
Peer reviewed. Published December 2020.  Full paper download.  https://rdcu.be/ceGs1

About budbromley

Bud is a retired life sciences executive. Bud's entrepreneurial leadership exceeded three decades. He was the senior business development, marketing and sales executive at four public corporations, each company a supplier of analytical and life sciences instrumentation, software, consumables and service. Prior to those positions, his 19 year career in Hewlett-Packard Company's Analytical Products Group included worldwide sales and marketing responsibility for Bioscience Products, Global Accounts and the International Olympic Committee, as well as international management assignments based in Japan and Latin America. Bud has visited and worked in more than 65 countries and lived and worked in 3 countries.
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