A better approach could be to genotype patients to determine their risk profile and best treatment, rather than testing everyone for infection and “vaccinating” everyone.
Genetic mechanisms of critical illness in Covid-19. Published Dec 2020.
GWAS study of 2244 critically ill patients.
“…There is now strong evidence that critical illness caused by Covid-19 is qualitatively different from mild or moderate disease, even among hospitalised patients. There are multiple distinct disease phenotypes with differing patterns of presenting symptoms13 and marked differential responses to immunosuppressive therapy.2 In patients without respiratory failure, there is a trend towards harm from treatment with corticosteroids, whereas among patients with critical respiratory failure, there is a very substantial benefit.2 On this basis, we consider patients with critical Covid-19 respiratory failure to have distinct pathophysiology. … We have discovered new and highly plausible genetic associations with critical illness in Covid -19.”
Pairo-Castineira, E., Clohisey, S., Klaric, L. et al. Genetic mechanisms of critical illness in Covid-19. Nature (2020).
Peer reviewed. Published December 2020. Full paper download. https://rdcu.be/ceGs1
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