It is worthwhile to point out again that these three “must have” vaccine characteristics do not exist with any of the current Covid-19 vaccines. “To our knowledge, all documented cases of vaccine resistance can be attributed to the absence of at least one of three key features that most vaccines possess:
1) the vaccine induces an immune response that protects hosts by targeting multiple virus epitopes simultaneously, thereby generating redundant and evolutionarily-robust protection,
2) the vaccine suppresses pathogen growth within hosts and stops transmission from vaccine-protected hosts, and
3) the vaccine-induced immune response protects against all circulating serotypes of the target pathogen.”
Only this part of #2 exists: “the vaccine suppresses pathogen growth within hosts” and in current Covid-19 vaccines even that partial specification is limited to growth of some pathogen variants.
All of the current Covid-19 vaccines are “leaky.”
Hat tip to Sergey Larionov for reminding me of this previously posted paper’s prescience, which becomes more obvious by day.
- PLOS Biology | November 9, 2020 Pdf at this link
Citation: Kennedy DA, Read AF (2020) Monitor for COVID-19 vaccine resistance evolution during clinical trials. PLoS Biol 18(11): e3001000. https://doi.org/10.1371/journal.pbio.3001000
Published: November 9, 2020